A few years ago, a 50-year-old man visited a hospital when he experienced shortness of breath and edema. But he had to visit a number of hospitals for years for examination as he struggled to pin point the name of the disease.

And one day, he felt tingling sensation in his toes and examined the heart. That was the time he had to face his rare disease called hereditary transthyretin amyloid cardiomyopathy (ATTR-CM).

Typically categorized as either wild type or hereditary, ATTR-CM is an ultra rare disease that has extremely limited patient size and the prevalence rate in South Korea has not been estimated. To this date, about over 120 types of genetic mutation have been reported, and apparen