Off-label refers to the use of drugs for an indication other than those approved by the Ministry of Food and Drug Safety.

Although people may question the need for off-label use when the appropriate use for a drug has already been set by the health authorities, these off-label prescriptions are made at the doctor’s discretion.

Often, off-label use of a drug is encouraged or shunned according the situation of each disease or drug. Voices on their necessity or non-necessity are also raised accordingly.

The latter goes for new oral anticoagulants (NOACs). Relevant societies and specialists have continuously raised concerns over the prescription of low-dose NOACs, but still,